Hygroscopicity Project Details
Improving delivery efficiency of inhaled medications is of utmost importance, as it will lead to reduction of side effects associated with unwanted mouth-throat deposition, and reduction of treatment costs associated with decreased drug dosage. In addition, many next generation inhaled medications require precise targeting and dosing within the airways to be clinically acceptable, effective, and safe. In this direction, Longest et al. (2012) proposed the enhancement of drug particles with hygroscopic excipients. With appropriate selection of the initial size of the particles and the drug-excipient ratio, it is possible to achieve optimum drug delivery at targeted areas of the airways, by harnessing the natural high humidity environment of the airways. In this study, we evaluate the delivery efficiency of drug-excipient composites using high-fidelity numerical simulations.