UCY-CompSci and ELPEN pharmaceutical have formed a research project agreement aiming to examine the airflow features and drug powder transport characteristics inside the ELPENHALER Dry powder inhaler via high-fidelity numerical simulations. Several configurations of ELPENHALER have been investigated such as single- and double-blister devices. Although the high computational cost prohibits to fully resolve the underlying physics (e.g. powder agglomeration / deagglomeration), simulations can provide valuable information, such as the device resistance and air distribution inside its passages, and powder-particle collision hotspots on the inhaler walls. Moreover, computational models which include both the device and an upper airway geometry have been developed in an effort to predict drug losses in the large airways (from mouth to around the seventh lung generation) as well as estimate the amount of drug that reaches the target locations in the peripheral lung. The findings from these studies can be utilized to improve future versions of the device.